Journal of Korean Geriatric Psychiatry


pISSN 1226-6329 / eISSN 2733-4600


대한노인정신의학회 (27권2호 65-70)

Influence of Anesthesia on Incidence of Dementias: 8-Year Follow-Up Study

마취 시행이 치매 발생에 미치는 영향: 8년 추적 연구

Surin Seo, MD, Won Seok William Hyung, MD, Seung-Hoon Lee, MD, PhD, Junhyung Kim, MD, PhD, Kwang-Yeon Choi, MD, PhD, HyunChul Youn, MD, PhD, and Hyun-Ghang Jeong, MD, PhD

고려대학교 의과대학 구로병원 정신건강의학과, 충남대학교 의과대학 충남대학교병원 정신건강의학과, 순천향대학교 의과대학 순천향대학교병원 정신건강의학과


Objective: Cognitive dysfunction is frequently reported after surgery and anesthesia in elderly patients. This study aims to investigate the incidence of dementia for eight years after anesthesia.
Methods: We extracted the data between 2007 and 2020 from the Health Insurance Review and Assessment Service Database. We analyzed risk of developing dementia after anesthesia using Cox proportional hazard models.
Results: Data were collected from 62,541 patient. Among them, subjects with and without anesthesia were 15,857 and 46,684,
respectively. Subjects with anesthesia had more hypertension, diabetes mellitus and hyperlipemia than those without anesthesia.
The risk of dementia incidence was found to increase 1.7 times in subjects with anesthesia (hazard ratio=1.751, 95% confidence
interval=1.596-1.921). Even after the correction for gender, age, and comorbidity, the statistical significance of this risk remained
(hazard ratio=1.662, 95% confidence interval=1.512-1.827).
Conclusion: Our findings suggest that anesthesia possibly contribute on cognitive impairment. Clinician might need closed
observation on cognitive function in patients after surgery and anesthesia.


Keywords: Anesthesia; Dementia; Surgery; Cognitive decline