Journal of Korean Geriatric Psychiatry


pISSN 1226-6329 / eISSN 2733-4600


대한노인정신의학회 (27권2호 59-64)

Usefulness of a Memory Complaint Questionnaire for Predicting Amyloid PET Positivity in Community-Dwelling Older Adults

지역사회 노인에서 아밀로이드 PET 양성 예측에 대한 주관적 기억력 저하 설문의 유용성

Min Hong Lee, MD, Min Jae Kang, MD, PhD, and Woo Jung Kim, MD, PhD

Department of Psychiatry, Severance Hospital, Yonsei University College of Medicine, Seoul, Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Institute of Behavioral Sciences in Medicine, Yonsei University College of Medicine, Seoul, Korea


Objective: This study aimed to assess the usefulness of a memory complaint questionnaire for predicting amyloid PET positivity in community-dwelling older adults.
Methods: We recruited community-dwelling older adults without history of dementia who wished to participate in the study
based on voluntary consent. We performed the Seoul Neuropsychological Screening Battery-Core (SNSB-C), Memory Age-associated Complaint Questionnaire (MACQ), Apolipoprotein E (ApoE) genotyping, and amyloid PET. According to the result of
the SNSB-C, participants with objective cognitive impairment were excluded, and finally 124 participants were included in this
study. We used receiver operating characteristic (ROC) curve and calculated area under the ROC curve (AUC) to evaluate usefulness of the MACQ compared to the result of ApoE genotyping for predicting amyloid PET positivity in cognitively unimpaired community-dwelling older adults.
Results: The mean age of the study participants was 73.3 years, and 69.4% were female. ROC curve with MACQ score and
with ApoE4 carrier was created and AUC of each model was calculated. AUC value was 0.660 for MACQ score, and 0.695 for
ApoE4 carrier. There was no statistically significant difference in AUC value (p=0.494).
Conclusion: In community-dwelling older adults without objective cognitive decline, the memory complaint questionnaire―
MACQ showed no significant difference with ApoE4 carrier for predicting amyloid PET positivity


Keywords: Aged; Amyloid deposits; Memory loss; Apolipoprotein E4.