Journal of Korean Geriatric Psychiatry

노인정신의학

pISSN 1226-6329 / eISSN 2733-4600


노인정신의학

대한노인정신의학회 (3권2호 129-139)

Neurobiology of Depression in Women

여성우울증의 신경생물학

전진숙(Jin-Sook Cheon)

Abstract

The important role that gonadal hormones play in women's life is also manifested in regulation of mood and behavior. Estrogen, in particular, has mostly positive effects on women's mood, while some periods of hormonal change like the postpartum, perimenstrual period and the perimenopause are associated with increased risk of depression. The propensity of women to develop depression seems to be due to a combined effect of genetics, gonadal hormones, and psychosocial factors. The sex difference of neuroanatomical response to mood, and changes in modulation of monoamine neurotransmitters by gonadal hormones, also seemed to be a risk factor to increase the vulnerability to depression in women.

Keywords

월경전불쾌장애,분만후우울증,폐경기증후군,변연계,에스트로겐,세로토닌, Premenstrual dysphoric disorder,Postpartum depression,Menopausal syndrome,Limbic system, Estrogen,Serotonin