pISSN 1226-6329 / eISSN 2733-4600
대한노인정신의학회 (26권2호 76-83)
Higher Fat-Related Body Composition Measurement and Lower Resting-State Inter-Network Functional Connectivity of APOE ε4 Carrier in Mild Cognitive Impairment Patients With Aβ Deposition
APOE ε4 보인자의 지방 관련 체성분 수치 증가에 따른 휴지기 신경망 간 기능적 연결성 감소: 아밀로이드 베타 단백질 침착 기억성 경도인지장애 환자를 대상으로
In Hyeok Choi, MD, Sheng-Min Wang, MD, PhD, Yoo Hyun Um, MD, PhD, Hyun Kook Lim, MD, PhD, Chang Uk Lee, MD, PhD, and Dong Woo Kang, MD, PhD
Objective: We aimed to evaluate the impact of interaction between APOE ε4 carrier status and body composition measurements
on intra- and inter-regional functional connectivity (FC) in mild cognitive impairment (MCI) patients with Aβ deposition.
Methods: MCI patients with and without APOE ε4 allele (carrier, n=86; non-carrier, n=95) underwent neuropsychological battery,
resting-state functional magnetic resonance imaging scans, positron emission tomography scans with [18F] flutemetamol, and bioelectrical impedance analysis for measuring body composition. We employed a priori defined regions of interest to investigate the intra- and
inter-network FC profiles of default mode network (DMN), central executive network (CEN), and salience network (SN).
Results: There was a significant interaction of APOE ε4 carrier status with body fat mass index, visceral fat area, and waist-hip
circumference ratio for inter-network FC between DMN and CEN, contributing higher fat-related body composition measurements
in the APOE ε4 carrier with lower DMN-CEN FC.
Conclusion: The present results highlight the detrimental effect of APOE ε4 carrier status on the associations between the fatrelated body composition measurements and FC in the MCI patients with Aβ accumulation.
Body composition; APOE ε4-carrier; Bioelectrical impedance analysis; Functional connectivity; Mild cognitive impairment
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