pISSN 1226-6329 / eISSN 2733-4600
대한노인정신의학회 (26권1호 12-17)
Reduced Volume of Anterior Corpus Callosum in Alzheimer’s Disease With Psychotic Symptoms: Cross-Sectional Magnetic Resonance Imaging Study
정신병적 증상을 동반한 알츠하이머병에서 앞쪽뇌량 부피의 감소: 자기공명영상 단면연구
Hyunji Lee, MD, Young-Min Lee, MD, PhD, Je-Min Park, MD, PhD, Byung-Dae Lee, MD, PhD, Eunsoo Moon, MD, PhD, Hee-Jeong Jeong, MD, PhD, Hwagyu Suh, MD, Kyungwon Kim, MD, PhD, Hak-Jin Kim, MD, PhD, Kyongjune Park, MD, PhD, and Kyung-Un Choi, MD, PhD
Objective: Although previous studies have shown association between anterior corpus callosum (ACC) and various psychotic disor- der, the effect of ACC on development on psychotic symptoms in Alzheimer’s disease (AD) is still unclear. The purpose of this study is to investigate the association of ACC with the development of psychosis in patients with AD.
Methods: This is a hospital based cross-sectional study of 241 AD patients. The main outcome measure is the volume of ACC that were measured as regions of interest with magnetic resonance imaging and the FreeSurfer analysis at baseline. Analysis of covari- ance and Logistic regression analysis conducted to assess the association between the volume of ACC and the presence of psychosis in AD, adjusting for age, education, Clinical Dementia Rating-Sum of Boxes, and total intracranial volume.
Results: We found that the volume of ACC is significantly reduced in AD with psychosis (AD+P) compared to AD without psychosis (AD-P) (774.27±142.96 vs. 833.09±142.04, p=0.005). The volume of ACC associated with the presence of psychosis in AD (odds ra- tio=0.995; 95% confidence interval=0.993-0.997; p=0.006).
Conclusion: We have found that reduced volume of ACC in AD+P, suggesting that ACC might play an important role in the underlying pathogenesis of development of psychotic symptoms in AD.
Anterior corpus callosum; Psychosis; Alzheimer’s disease.
PDF