대한노인정신의학회

Objective: The aim of this study was to reveal the association between the depressive symptom and cognitive function of participants with normal cognitive function, mild cognitive impairment (MCI), and dementia in a large-scale community elderly cohort.
Methods: A total of 6,338 elderly participants who participated in the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) from November 2010 to October 2012 were evaluated through cross-sectional analysis. Cognitive evaluation
was conducted with Korean Version of Mini Mental Status Exam for Dementia Screening (MMSE-DS) and Consortium to Establish
a Registry for Alzheimer’s Disease Assessment Packet (CERAD) neuropsychological tests, and depressive symptoms were evaluated
with Revised Korean Version of the Geriatric Depression Scale (GDS-KR).
Results: 4,352 normal cognitive elderly participants, 1,748 MCI and 238 dementia participants were enrolled in the study. Correlation analysis showed a significant negative correlation between MMSE-DS and GDS-KR in the normal elderly group and participants with MCI, but not in dementia participants. This was the same in the correlation between CERAD-TS (total score) and GDSKR score.
Conclusion: This study found that worse cognitive function in the community cohort worsened depressive symptoms in groups
with normal and MCI, but no significant correlation was observed in patients with dementia.

Depression, Mild cognitive impairment, Dementia, Community, Elderly