pISSN 1226-6329 / eISSN 2733-4600
대한노인정신의학회 (24권2호 99-102)
Effect of Fetal Sex Hormone on the Development of Alzheimer’s Disease in Woman: A Cross-Sectional Study Using 2D/4D Digit Length Ratio
태아기 성호르몬이 여성의 알츠하이머병의 발병에 미치는 영향
강태욱(Tae Uk Kang);이영민(Young Min Lee);박제민(Je Min Park);이병대(Byung Dae Lee);문은수(Eunsoo Moon);정희정(Hee Jeong Jeong);김수연(Soo Yeon Kim);이강윤(Kang Yoon Lee);서화규(Hwagyu Suh);정영인(Young-In Chung)
Objective: The purpose of this study is to investigate an association between sex-hormone exposure during fetal period and the development of Alzheimer’s disease (AD). Methods: Twenty four AD patients and 25 normal controls were included from Memory Impairment Clinic of Pusan National University Hospital in Korea. Subjects are measured the ratio of the length of the second to the fourth digit (2D/4D) to estimate fetal sex-hormone exposure. Analysis of covariance was used to investigate an association between fetal sex-hormone exposure and the development of AD after adjusting age, education level, Korean Mini-Mental Status Examination and head circumference. Results: We found that the females with AD had significantly lower 2D/4D ratios than the female controls. In the females with AD, the 2D/4D ratios in the left hand was 0.021 and 0.017 in the right hand compared with the controls. Conclusion: Our findings suggest that the development of AD in female may be related with higher testosterone and lower estrogen exposure during fetal period.
Alzheimer’s disease,Fetal sex hormone,2D/4D ratios
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