pISSN 1226-6329 / eISSN 2733-4600
대한노인정신의학회 (24권1호 37-41)
Decreased Hippocampal Metabolism in Amnestic Mild Cognitive Impairment: Positron Emission Tomography Study
기억장애성 경도인지장애 환자에서 해마대사량의 감소: 양전자방출단층촬영연구
박찬흠(Chan hum Park); 이영민(Young Min Lee); 박제민(JeMin Park); 이병대(Byung Dae Lee); 문은수(EunSoo Moon); 정희정(Hee Jeong Jeong); 김수연(Soo Yeon Kim); 이강윤(Kang Yoon Lee); 서화규(Hwagyu Suh); 박혜경(Hye Kyung Park); 김학진(Hak-Jin Kim); 박경준(Kyoungjune Park); 문치웅(Chi-Woong Mun); 정영인(Young-In Chung)
Objective: Little is known about factors influencing of hippocampal metabolism (HM) in mild cognitive impairment (MCI). Our objective was to determine whether HM in patients with amnestic MCI (aMCI) is decreased than non-amnestic MCI (naMCI). Methods: Overall, 32 MCI patients underwent 18F-fluorodeoxyglucose-positron emission tomography. They were characterized as aMCI (n=18) or naMCI (n=14) according to comprehensive neuropsychological criteria. Analysis of variances were used to assess differences on HM between aMCI and naMCI after controlling age, sex, education and Korean version of Mini Mental Status Examination. Results: We found that HM was more decreased in aMCI than naMCI. This result was not changed after controlling hippocampal volume. Conclusion: Our findings suggest that aMCI is associated with decreased HM in MCI.
Amnestic mild cognitive impairment, Hippocampal metabolism, Hippocampal volume
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