Journal of Korean Geriatric Psychiatry

노인정신의학

pISSN 1226-6329 / eISSN 2733-4600


노인정신의학

대한노인정신의학회 (20권1호 1-8)

Neurobiological Mechanism of Memory

기억의 신경생물학적 기전

정영인(Young In Chung);이영민(Young Min Lee);문은수(Eun Soo Moon)

Abstract

Memory is one of the most important mental mechanisms which is crucial for us to adapt to environmental surroundings and to maintain our identity. The neurobiological mechanisms for memory are based upon the synaptic plasticity that involve both func-tional and structural changes at the synapses in the neural circuits participating in learning and memory. Memory is not a single process but has two forms of short-term and long-term memory that are two independent but overlapping processes that blend into one another. The short-term memory depends upon the functional change of synaptic strength but the long-term memory requires anatomic changes of synapses in the neural circuit. Memory storage seems to use elements of a common genetic switch, involving cyclic adenosine monophospate (cAMP)-dependent protein kinase, mitogen activated protein kinase, and cAMP response element-binding protein, to convert short-term memory into long-term memory.

Keywords

Short-term memory,Long-term memory,Neurobiological mechanism,단기기억,장기기억,신경생물학적 기전.