pISSN 1226-6329 / eISSN 2733-4600
대한노인정신의학회 (21권2호 106-112)
Gender-Specific Influence of Education in Cognitive Subdomains in Alzheimer’s Disease : A Clinical Research Center for Dementia of South Korea Study
알츠하이머 치매 환자에서 성별에 따라 교육 성취도가 영역별 인지기능에 미치는 영향 : A Clinical Research Center for Dementia of South Korea Study
이준노(Jun Ro Lee);이춘수(Chunsoo Lee);최준배(Junbae Choi);강효신(Hyo Shin Kang);임신원(Shin Won Lim);나덕렬(Duk L. Na);김성윤(Seong Yoon Kim);이재홍(Jae-Hong Lee);한설희(Seol-Heui Han);최성혜(Seong Hye Choi);김상윤(Sang Yun Kim);김도관(Doh Kwan Kim)
Objective：We aimed to find the sex differences of the way how educational attainment influence on cognitive function in patients with Alzheimer’s disease (AD). Methods：We recruited 424 patients with AD from a large hospital-based multi-center cohort. We evaluated cognitive subdomains using the Seoul Neuropsychological Screening Battery-Dementia version. We employed multiple linear regression analysis to compare the score of cognitive subdomains between the groups with high versus low educational attainment based on the high school graduate. Interaction between educational attainment and sex was also included in the analysis. Results：High and low educational attainment group had 33.0% and 67.0% of patients in the study population. In the multiple regression analysis, score of all cognitive subdomains were significantly higher in the high educational attainment group. The score of attention was also significantly affected by interaction between educational attainment and sex. This result may be helpful to develop cognitive intervention therapy. Conclusion：In the female patients with AD, educational attainment showed higher influence on the attention score.
Alzheimer’s disease,Sex,Education,Cognitive function
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