pISSN 1226-6329 / eISSN 2733-4600
대한노인정신의학회 (21권2호 87-91)
Association of Temporal Lobe Atrophy and Psychosis in Patients with Alzheimer’s Disease
알츠하이머병 환자에서 정신병과 측두엽 위축과의 연관성
손제현(Je Hyun Sohn);이영민(Young Min Lee);박제민(Je Min Park);이병대(Byung Dae Lee);문은수(Eun Soo Moon);정희정(Hee Jeong Jeong);김수연(Soo Yeon Kim);이강윤(Kang Yoon Lee);김지훈(Ji-Hoon Kim);정영인(Young-In Chung)
Objective：The purpose of this study is to investigate the difference on regional volume in temporal lobe between Alzheimer’s disease patients with psychosis (AD+P) and Alzheimer’s disease patients without psychosis (AD-P). Methods：Altogether, 24 AD+P and 25 AD-P matched age, gender, and clinical dementia rating sum of box (CDR-SOB) were include from a Memory impairment clinics of Pusan National University Hospital in Korea. AD+P were diagnosed according to Jeste and Finkel’s proposed diagnostic criteria for psychosis of Alzheimer’s disease. Grey matter volume of temporal lobe was measured with 3-tesla magnetic resonance imaging and freesufer analysis. Analysis of variance was used to investigate the association between temporal lobe and AD+P after controlling age, gender, education years, CDR-SOB and total intracranial volume. Results：We found an association between AD+P and reduced grey matter volume in total temporal lobe as well as in specific temporal regions such as left middle temporal lobe, left inferior temporal lobe, both hippocampus and both fusiform. Conclusion：Our findings suggest that AD+P are associated with reduced grey matter volume of temporal lobe.
Alzheimer’s disease,Psychosis,Grey matter volume,Temporal lobe
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