pISSN 1226-6329 / eISSN 2733-4600
대한노인정신의학회 (20권2호 75-79)
A Voxel Wise Analysis of Cerebral Beta Amyloid Retention in Healthy Controls and Subjects with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease
18F-Florbetaben을 이용한 대조군과 기억성 경도인지장애 및알츠하이머병 환자군의 아밀로이드 침착 패턴 양상 : 복셀 기반 영상분석
조예니(Yeani Cho);엄유현(Yoo Hyun Um);김태원(Tae-Won Kim);서호준(Ho-Jun Seo);정종현(Jong-Hyun Jeong);홍승철(Seung-Chul Hong);한진희(Jin-Hee Han);백인호(In-Ho Baek);임현국(Hyun-Kook Lim)
Department of Psychiatry, 2 Keyo Hospital, Uiwang, Korea Objective：The purpose of the study was to compare cortical amyloid deposition using 18F-florbetaben and positron emission tomography (PET) in healthy controls and subjects with amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD). Methods：We investigated 25 patients : 10 age-matched healthy controls, 10 patients with aMCI and 5 with AD. All participants underwent PET after intravenous injection of 300 MBq of 18F-florbetaben. The 90 min post-injection brain PET data were analysed using statistical parametric mapping. Results：When compared to healthy controls, amyloid deposition was significantly higher in frontal lobe medial frontal gyrus, limbic lobe posterior cingulate, parietal lobe precuneus, sub-loba insula, temporal lobe superior temporal gyrus, parietal lobe inferior parietal lobule, temporal lobe middle temporal gyrus, parietal lobe supramarginal gyrus, occipital lobe middle temporal gyrus of patient group (family wise error correction p<0.05). Conclusion：These results indicate 18F-florbetaben to be an efficacious β-amyloid-targeted tracer. Subjects with aMCI, AD could be easily differentiated from healthy controls by assessment of the PET data.
β-amyloid,Positron emission tomography,18F-florbetaben,Alzheimer’s disease
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