pISSN 1226-6329 / eISSN 2733-4600
대한노인정신의학회 (19권2호 1-4)
Reduced Cortical Thickness in Patients with Late Life Depression without Cerebral Vascular Disease
뇌혈관질환이 없는 노년기 우울증 환자에서 피질 두께의 감소
이강윤(Kang Yoon Lee);이영민(Young Min Lee);박제민(Je Min Park);이병대(Byung Dae Lee);문은수(Eun Soo Moon);정희정(Hee Jeong Jeong);정영인(Young-In Chung);김지훈(Ji-Hoon Kim)
Objective：The aim of this study is to compare cortical thickness in late life major depression patients without cerebral vascular disease (CVD) with that of non-depressed normal comparison subjects using magnetic resonance imaging (MRI). Methods：Altogether, 47 subjects were finally recruited from the Memory impairment clinics of Pusan National University Hospital in Korea. All subjects (late life major depression patients without CVD : n=21, matched non-depressed normal compari-son subjects : n=26) underwent 3-tesla MRI. Results：Late life major depression patients without CVD showed reduced cortical thickness in left precuneus, left inferior temporal gyrus, and left cuneus compared with non-depressed normal comparison subjects. Conclusion：Our findings suggest that late life major depression without CVD is associated with reduced cortical thickness.
Late life major depression,Cortical thickness,Magnetic resonance imaging,노년기 우울증,피질 두께,뇌자기공명영상검사.
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