pISSN 1226-6329 / eISSN 2733-4600
대한노인정신의학회 (18권2호 69-75)
Alcohol Consumption as Risk Factor for Progression from Mild Cognitive Impairment to Dementia : A Clinical Research Center for Dementia of South Korea Study
알코올 섭취가 경도인지장애의 치매 진행에 미치는 영향
김진영(Jinyoung Kim);김상하(Sangha Kim);명우재(Woojae Myung);강효신(Hyo Shin Kang);나덕렬(Duk L. Na);김성윤(Seong Yoon Kim);이재홍(Jae-Hong Lee);한설희(Seol-Heui Han);최성혜(Seong Hye Choi);김상윤(Sang Yun Kim);김도관(Doh Kwan Kim)
Objective：Patients with mild cognitive impairment (MCI) are at high risk for dementia. Excessive alcohol consumption is known to adversely affect cognitive function. This study aimed to investigate the relationship between alcohol consumption and the risk for dementia in a cohort of MCI patients. Methods：Participants (n=416) with (MCI) who met Petersen’s criteria were recruited from a nationwide, prospective cohort study of dementia and were followed for a median of 17.52 months (range 5.4-63.48). Alcohol consumption was evaluated at baseline. Results：One hundred twenty seven individuals (30.5%) developed incident dementia (115 Alzheimer disease) during follow-up. Patients with current alcohol consumption at baseline had a higher rate of progression to Alzheimer’s dementia than those without current alcohol consumption (hazard ratio 1.61 ; 95% confidence interval 1.03 to 2.53). Conclusion：Alcohol consumption may increase the risk of progression to Alzheimer’s dementia in patients with MCI.
알츠하이머병,알코올,경도인지장애, Alzheimer disease,Alcohol,Mild cognitive impairment
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