pISSN 1226-6329 / eISSN 2733-4600
대한노인정신의학회 (17권1호 20-25)
Association between Cognitive Subdomains and Extrapyramidal Signs in Alzheimer Disease : A Clinical Research Center for Dementia of South Korea (CREDOS) Study
알츠하이머 치매 환자에서의 추체외로 증상과 영역별 인지기능의 연관성
최준배(Junbae Choi);명우재(Woojae Myung);송지혜(Jihye Song);김상하(Sang Ha Kim);윤혜연(Hyeyeon Yoon);강효신(Hyo Shin Kang);나덕렬(Duk L. Na);김성윤(Seong Yoon Kim);이재홍(Jae-Hong Lee);한설희(Seol-Heui Han);최성혜(Seong Hye Choi);김상윤(SangYun Kim);김도관(Doh Kwan Kim)
Objectives：We aimed to investigate the prevalence of Extrapyramidal signs (EPS) and the associations between EPS and cognitive subdomains in patients with Alzheimer disease (AD). Methods：We recruited 1,324 patients with AD from the Clinical Research of Dementia of South Korea (CREDOS), a hospital based cohort study with fifty-six participating hospitals. We estimated cognitive subdomain using the Seoul Neuropsychological Screening Battery-Dementia version (SNSB-D). Dementia severity was measured by Clinical Dementia Rating Sum of Boxes (CDR- SB) and Korean version of Mini-Mental Status Examination (K-MMSE). The EPS group was defined by the presence of at least one EPS based on a focused neurologic examination. Results：The prevalence of patients with EPS was 11%. These had higher CDR-SB scores than non-EPS group. After controlling for demographic, radiological, and dementia severity (CDR-SB) factors, EPS group showed lower cognitive ability in the subdomains for visuospatial and frontal-executive function than non-EPS group. The patients with EPS were showed significantly higher scores in the subdomain for memory function. Conclusion：The presence of EPSs in patients with AD was associated with lower visuospatial, frontal-executive function and higher memory function.
알츠하이머 치매,추체외로 증상,인지능력 Alzheimer disease,Extrapyramidal signs,Cognitive symptoms
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