대한노인정신의학회

Objectives : This study aimed to investigate the serum levels of total homocysteine (tHcy), folate and vitamin B12 in Alzheimer＇s disease and mild cognitive impairment. Methods : Sixty-one Alzheimer＇s disease (AD) patients, forty mild cognitive impairment (MCI) patients and forty-four normal controls were studied. The serum homocysteine (tHcy), folate, and vitamin B12 were measured and MMSE-K, GDS were evaluated for cognitive function. Results : Serum tHcy levels were significantly higher and folate levels were lower in patients with AD than in controls. And also serum folate levels were lower in MCI than in controls. Vitamin B12 did not have a significant difference among three groups. The serum homocysteine and folate levels shows significant correlation with MMSE-K. Conclusion : Elevated tHcy levels and low blood levels of folate were associated with AD. Serum folate were significantly lower levels in MCI than in controls. We suggested that serum tHcy, folate are useful risk markers for the development of cognitive dysfunction.

호모시스테인,엽산,비타민 B12,알쯔하이머병,경도인지장애, Homocysteine,Folate,Vitamin B12,Alzheimer＇s disease,Mild cognitive impairment