Journal of Korean Geriatric Psychiatry

노인정신의학

pISSN 1226-6329 / eISSN 2733-4600


노인정신의학

대한노인정신의학회 (13권1호 38-43)

An Optimized Voxel-Based Morphometry of Gray Matter Reduction in Patients with Alzheimer's Disease

최적화 화소 기반 형태분석 방법을 이용한 알츠하이머 병환자의 회백질 용적감소의 정량적 분석

임현국(Hyun Kook Lim);윤동환(Dong Whan Yoon);원왕연(Wang Youn Won);이철(Chul Lee);이창욱(Chang Uk Lee)

Abstract

Objective : Optimized voxel based morphometry (VBM) has been increasingly applied to investigate differences in brain morphology between a group of Alzheimer's Disease (AD) patients and control subjects. Optimized VBM permits comparison of gray matter (GM) volume at voxel-level from the entire brain. The purpose of this study was to assess the regional GM volume loss measured by optimized VBM in AD compared to controls Methods : Twenty-three AD patients and 20 cognitively normal elderly control subjects included in this study. To improve the VBM performance, the study specific template and the probability maps were generated from the control subjects. Results : Optimized VBM analysis revealed GM loss, including hippocampus, amygdala, anterior cingulate, posterior cingulate, insula, frontal lobe and middle temporal complex in the AD group as compared to normal control group Conclusion : The VBM results confirmed previous findings of temporal lobe and limbic lobe atrophic changes in AD, and suggest that these abnormalities may be confined to specific sites within that lobe, rather than showing a widespread distribution.

Keywords

알츠하이머치매,최적화 화소 기반 형태분석, Alzheimer's disease,Optimized VBM