pISSN 1226-6329 / eISSN 2733-4600
대한노인정신의학회 (6권1호 49-56)
Apolipoprotein ε4 and Cognitive Function, Daily Living Ability and Behavioral Symptoms of Dementia
아포지단백(Apolipoprotein) ε4 유전자형과 치매환자의 인지기능, 일상생활기능 및 행동증상
김영돈(Young-Don Kim);이창화(Chang-Hwa Lee);엄기춘(Ki-Choon Eum);김동희(Dong-Hee Kim);윤경식(Kyeong-Sik Yoon)
Objectives：We investigated the relationship between apolipoprotein ε4 and clinical features of dementia. Methods：Samples were obtained from 33 dementia patients in Korea, Buyeo Geriatric Hospital and apolipoprotein E polymorphisms were analysed using polymerase chain reaction and restriction fragment length polymorphism. The multidimensional evaluating methods (MMSE-K, B-ADL, BEHAVE-AD, GDS, GMHR) for dementia were performed to analyze relationship with Apolipoprotein E genotypes. Results：The distributions of the apolipoprotein E genotypes of the dementia patients were presented by ε3/ε3 (58%), ε3/ε4 (22%), ε2/ε3 (15%), and ε4/ε4 (0%). There is no significant relationship between apolipoprotein ε4 and the findings of multidimensional evaluating measures. Conclusion：We could not find the association between apolipoprotein ε4 and the scores of the multidimensional evaluating measures of dementia patients. The results suggested that apolipoprotein ε4 might not play a main role in cognitive function, daily living ability and behavioral symptoms of dementia.
치매,Apolipoprotein E 유전자형,치매평가척도, Dementia,Apolipoprotein ε4,Multidimensional measures
PDF