pISSN 1226-6329 / eISSN 2733-4600
대한노인정신의학회 (28권1호 1-6)
The Role of Astrocyte Related to Early Diagnosis of Alzheimer’s Disease Dementia
알츠하이머병치매 조기진단 관련 별세포의 역할
IL Han Choo, MD, PhD
Department of Neuropsychiatry, College of Medicine, Chosun University, Gwangju, Department of Psychiatry, Chosun University Hospital, Gwangju, Korea
Astrocyte occupies 20%-40% of all glial cells in human central nervous system (CNS) and is important regulator of CNS inflammatory response. Astrocytes are responsible for controlling neuronal and synaptic homeostasis and playing a critical role in the
maintenance of redox status. Reactive astrogliosis, astrocyte remodeling, clasmatodendrosis, and paralysis are related to Alzheimer’s
disease dementia (AD). Various astrocyte biomarkers in AD have been applied. Regarding positron emission tomography imaging,
radioisotopes such as [11C]-deuterium-L-deprenyl, [18F]-(S)-(2-methylpyrid-5-yl)-6-[(3-fluoro-2-hydroxy)propoxy]quinoline,
[11C]-(2-(4,5-dihydro-1H-imidazol-2-yl)-1-methyl-1H-indole) have been proposed for surrogate markers of astrogliosis. There is also
now a steadily growing interest in GFAP (glial fibrillary acidic protein) and S100 as cerebrospinal fluid and blood markers. In the future, early intervention related to reactive astrogliosis would make a clue for the early diagnosis and treatment of Alzheimer’s disease.
Astrocyte; Alzheimer’s disease dementia; Biomarkers; Early diagnosis.
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