대한노인정신의학회

Objective: This study aimed to assess the usefulness of a memory complaint questionnaire for predicting amyloid PET positivity in community-dwelling older adults.
Methods: We recruited community-dwelling older adults without history of dementia who wished to participate in the study
based on voluntary consent. We performed the Seoul Neuropsychological Screening Battery-Core (SNSB-C), Memory Age-associated Complaint Questionnaire (MACQ), Apolipoprotein E (ApoE) genotyping, and amyloid PET. According to the result of
the SNSB-C, participants with objective cognitive impairment were excluded, and finally 124 participants were included in this
study. We used receiver operating characteristic (ROC) curve and calculated area under the ROC curve (AUC) to evaluate usefulness of the MACQ compared to the result of ApoE genotyping for predicting amyloid PET positivity in cognitively unimpaired community-dwelling older adults.
Results: The mean age of the study participants was 73.3 years, and 69.4% were female. ROC curve with MACQ score and
with ApoE4 carrier was created and AUC of each model was calculated. AUC value was 0.660 for MACQ score, and 0.695 for
ApoE4 carrier. There was no statistically significant difference in AUC value (p=0.494).
Conclusion: In community-dwelling older adults without objective cognitive decline, the memory complaint questionnaire―
MACQ showed no significant difference with ApoE4 carrier for predicting amyloid PET positivity

Keywords: Aged; Amyloid deposits; Memory loss; Apolipoprotein E4.