pISSN 1226-6329 / eISSN 2733-4600
대한노인정신의학회 (29권2호 54-60)
Differential Association of Serum Vitamin D Level With Episodic Memory According to Aβ Positivity Status in Nondemented Older Adults
비치매 노인에서 아밀로이드 베타 양성 여부에 따른 혈청 비타민 D 농도와 삽화기억 간 연관성 차이
Junha Park, MD, Min Soo Byun, MD, PhD, Dahyun Yi, PhD, Hyejin Ahn, MA, Joon Hyung Jung, MD, Nayeong Kong, MD, Yoon Young Chang, MD, Gijung Jung, RN, PhD, Jun-Young Lee, MD, PhD, Yu Kyeong Kim, MD, PhD, Yun-Sang Lee, MD, PhD, Koung Mi Kang, MD, PhD, Chul-Ho Sohn, MD, PhD, and Dong Young Lee, MD, PhD for the KBASE Research Group*
Departments of Psychiatry, 11Nuclear Medicine, and 12Radiology, Seoul National University College of Medicine, Seoul, Departments of Neuropsychiatry and 13Radiology, Seoul National University Hospital, Seoul, Seoul National University Dementia Research Center, Seoul, Institute of Human Behavioral Medicine, Seoul National University Medical Research Center, Seoul, Interdisciplinary Program of Cognitive Science, Seoul National University College of Humanities, Seoul, Department of Psychiatry, Chungbuk National University Hospital, Cheongju, Department of Psychiatry, Keimyung University Dongsan Medical Center, Daegu, Department of Psychiatry, Inje University Sanggye Paik Hospital, Seoul, Departments of Neuropsychiatry and 10Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea
Objective: We examined the association between serum vitamin D levels and episodic memory and tested whether this association was modified by β-amyloid (Aβ) positivity in nondemented older adults.
Methods: A total 427 nondemented older adults were included for this study. All participants underwent clinical assessments, amyloid positron emission tomography and MRI, and serum 25-hydroxyvitamin D (25(OH)D) levels measurement. For evaluation of episodic memory, performances on immediate recall (IR), delayed recall (DR), and recognition (Rc) of the Logical Memory Subtest of the Wechsler Memory Scale–Fourth Edition were assessed for all participants.
Results: Overall, serum 25(OH)D levels were positively associated with Rc. In addition, the interaction between serum 25(OH)D levels and Aβ positivity was significant for the association between serum 25(OH)D levels and all three measurements of episodic memory. Subsequent subgroup analyses revealed significant positive association between serum 25(OH)D levels and IR, DR, and Rc in the Aβ-positive group, but not in the Aβ-negative group.
Conclusion: Our findings suggest a differential association between serum vitamin D level and episodic memory according to Aβ positivity status in nondemented older adult, indicating the importance of serum vitamin D in episodic memory, particularly among those within Alzheimer’s disease spectrum.
Vitamin D; Alzheimer’s disease; Beta-amyloid; Episodic memory
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