pISSN 1226-6329 / eISSN 2733-4600
대한노인정신의학회 (26권1호 18-22)
Choroid Plexus and Its Association of Subtypes of Delusion in Patient With Alzheimer’s Disease
알츠하이머병 환자에서 맥락망총과 망상아형과의 연관성
Sung-Mi Son, MD, Young-Min Lee, MD, PhD, Je-Min Park, MD, PhD, Byung-Dae Lee, MD, PhD, Eunsoo Moon, MD, PhD, Hee-Jeong Jeong, MD, PhD, Hwagyu Suh, MD, Kyungwon Kim, MD, PhD, Hak-Jin Kim, MD, PhD, Kyongjune Park, MD, PhD, Kyung-Un Choi, MD, PhD
Objective: This study examined the volume of choroid plexus across AD without delusion (AD-D), AD with paranoid delusion (AD+PD), and AD with misidentification delusion (AD+MD).
Methods: This is a hospital based cross-sectional study of patients with AD. The main outcome measure is the volume of choroid plexus that were measured as regions of interest with magnetic resonance imaging and the FreeSurfer analysis at baseline. Analysis of co- variance (ANCOVA) was conducted to compare the differences on the volume of choroid plexus across AD-D, AD+PD, and AD+MD af- ter controlling demographics.
Results: There was no volume difference in the both choroid plexus between AD-D and AD+D. However, the volumes of both cho- roid plexus were significantly reduced in AD+MD compared to AD+PD.
Conclusion: Our study demonstrates that AD+MD has significantly reduced volumes of choroid plexus compared to AD+PD. These findings suggest that AD+MD and AD+PD may have different pathophysiological mechanisms related to neuroimmune re- sponses in the choroid plexus.
Choroid plexus; Alzheimer’s disease; Misidentification delusion.
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